Extended Release Injectables: Polymer Design, Formulation and Processing for Success
Tuesday, July 27th - 9am EDT
This presentation will provide scientists and technical stakeholders working in drug delivery with a detailed overview on an exciting extended release technology platform for parenteral applications based on bioresorbable polymers (lactide, glycolide, caprolactone chemistries and some novel PEGylated variants for newer/complex delivery needs). The session will explore control mechanisms, demonstrating how theoretical chemistry is coupled with formulation knowledge in different formulation formats including in-situ forming implants, microspheres/nanoparticles and pre-formed solid implants to successfully accomplish extended release drug delivery over periods of days, weeks and up to several months. Ashland will also highlight how customized and novel chemistries can be used to overcome technical development challenges for respective molecule delivery strategies. Existing commercial products will be examined to highlight the breadth of release profiles achievable, types of molecules, indications, drug loading limits achieved to-date and successful formulation formats. Additionally, details on the technical challenges beyond formulation including processing, stability and sterilization will be discussed. Processing case studies involving hot melt extrusion (HME) optimization and more than ten different particle production technologies in the creation of microspheres and nanoparticles will be explained.