Modulation of oral drug delivery using barrier membrane coating of multiparticulate systems
Tuesday, July 27th - 9am EDT
Oral drug delivery remains the most desired route of administration of active pharmaceutical ingredients. Multiparticulates dosage forms offer benefits of reduced gastrointestinal variability, improved compliance, and dose flexibility. Various drug release profiles are feasible through the application of immediate, delayed or extended release coatings on drug layered multiparticulates. In this forum, different formulation approaches and examples will be presented to develop extended release multiparticulates dosage forms. Ethylcellulose is a commonly used polymer in barrier membrane coating applications, both for aqueous and solvent based systems. The use of pore-formers and film coating thickness are used to modulate the drug release profiles from barrier membrane coated multiparticulates. Aqueous application of ethylcellulose is environmentally friendly and minimizes the safety concerns of handling solvents. Case studies will used to demonstrate the impact of formulation variables and processing conditions of two aqueous ethylcellulose dispersions (Surelease® Ethylcellulose Dispersion Type B NF and Aquacoat® ECD).